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Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model.

Endocrinology. 2016; 
Görtz GE, Moshkelgosha S, Jesenek C, Edelmann B, Horstmann M, Banga JP, Eckstein A, Berchner-Pfannschmidt U.
Products/Services Used Details Operation
Monoclonal Antibody Services 04 Santa Cruz Biotechnology, sc- 7816 Santa Cruz Biotechnology, sc- 32 262 GenScript, A00380 Sigma-Aldrich, A2547 Santa Cruz Biotechnology, sc- 34 067 NOVUS Biologicals, NB100 –56 127 Cell Signaling, #2118 Sigma-Aldrich, A5420 human, monoclonal, IgG 0,1 ␮g/ml TSHR TSHR (N-19) goat, polyclonal, IgG 1:200 TSHR TSHR (4C1) mouse, monoclonal, IgG2a 0,4 ␮g/␮l IGF-1R ␣-SMA HAS2 IGF-1R Antibody (Ab-1161) Anti-␣ Smooth Muscle Aktin Hyaluronan synthase2 (S-15) rabbit, polyclonal, IgG mouse, monoclonal, IgG goat, polyclonal, IgG 1:500 1:500 1:200 CD40 CD40/TNFRSF5 Antibody rabbit, polyclonal, IgG 1:1000 GAPDH IgG GAPDH (14C10) rabbit mAb Anti-Goat IgG (whole molecule) -Peroxidase Anti-Mouse IgG (Fab specific)- Peroxidase Anti-Rabbit IgG (whole molecule)-Peroxidase Rat F(ab)2 IgG (H ⫹ L) Fluorescein-conjugated Antibody Sheep IgG (H ⫹ L) Fluorescein- conjugated Antibody Goat anti-Mouse IgG (H ⫹ L) FITC conjugate Rat IgG2A Isotype Control rabbit, monoclonal, IgG rabbit, IgG 1:1000 1:5000 IgG Sigma-Aldrich, A2304 goat, IgG 1:5000 IgG Sigma-Aldrich, A0545 goat, IgG 1:5000 IgG R&D Systems, F0104B rat, polyclonal, IgG 10 ␮l/106 cells IgG R&D Systems, F0125 donkey, polyclonal, IgG 10 ␮l/106 cells 5 ␮g/ml IgG Thermo Scientific, F-2761 R&D Systems, MAB006 R&D Systems, MAB0061 R&D Systems, 5– 001- A BioLegend, 400 101 Santa Cruz Biotechnology, sc- 3878 mouse, polyclonal, IgG IgG rat, monoclonal, clone 54 447 0,5 ␮g/␮l IgG Rat IgG2B Isotype Control rat, monoclonal, clone 141 945 0,5 ␮g/␮l IgG Purified Sheep IgG normal sheep serum 0,5 ␮g/␮l IgG IgG Purified Mouse IgG1 Normal Mouse IgG2a mouse (BALB/c), IgG1 mouse, IgG2a 0,1 ␮g/ml 1:5 * Antigen sequences not known. Get A Quote

摘要

A mouse model of Graves' orbitopathy (GO) induced by genetic immunization of human TSH receptor (TSHR) A-subunit encoding plasmid has recently been established. The orbital pathology was characterized by adipogenesis, myopathy and fibrosis. Human orbital fibroblasts (OFs) express TSHR and IGF-1 receptor (IGF-1R) and are considered to be pathogenic in GO. We established conditions for growing ex vivo cultures of mouse OFs (mOFs) from orbital tissue of animals undergoing GO and controls. Early passage mOFs showed characteristic fibroblast morphology and expressed mesenchymal stem cell markers including a strong expression of CD90.2 and CD40, whereas display of CD73 and all other leucocyte markers was uniformly ab... More

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