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Interferon as a Mucosal Adjuvant for an Influenza Vaccine in Pigs.

Virol Sin. 2019; 
Liu L,, Fan W, Zhang H, Zhang S, Cui L,, Wang M,, Bai X,, Yang W,, Sun L,, Yang L, Liu W,, Li J,.
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Recombinant Antibody Services The recombinant PoIFNa was treated to remove LPS using a ToxinEraserTM Endotoxin Removal Kit (GenScript), following the manufacturer’s directions; it was then diluted and filtered through a 0. Get A Quote

摘要

Interferon, a natural protein that is produced by a variety of cells during viral infection, activates the transcription of multiple functional genes in cells, regulates synergy among various signaling pathways, and mediates many biological functions such as antiviral activity, immune regulation, and cell growth. However, clinical research on interferon in livestock is lacking. In this study, recombinant porcine interferon (PoIFNα) was used as an adjuvant, in combination with inactivated influenza virus, to vaccinate 6-week-old pigs via nasal infusion. The transcription of target genes was then monitored and the functions of PoIFNα were determined with respect to the activation of mucosal immunity. We found t... More

关键词

Cytokines; H1N1 influenza virus; Intranasal administration; Porcine interferon α (PoIFNα)