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Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.

Thromb Haemost. 2019; 
Larsen JB, Laursen MA, Hvas CL, Larsen KM, Thiel S, Hvas AM,.
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Bacterial Expression System As compared with the published detailed descriptions,35,36 the following modifications were made for the MASP-1 and H- ficolin assays: For MASP-1, the plates were coated with murine anti-MASP-1 antibodies (clone 1H1G6, Genscript, lot no A217100014) instead of the previously used antibody. Get A Quote

摘要

Activation of the complement system is part of the dysregulated immune response in sepsis. The mannose-binding lectin-associated serine proteases (MASP)-1 and -2 activate the lectin pathway of the complement system. Besides, these proteins can activate coagulation in vitro. However, the role of the lectin pathway proteins in the development of sepsis-related disseminated intravascular coagulation (DIC) is only sparsely investigated.,This article investigates the association between lectin pathway proteins and coagulation disturbances in septic shock patients.,We included 36 septic shock patients from the intensive care unit, Aarhus University Hospital, Denmark. Blood samples were obtained within 24 hours after ... More

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