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Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.

JAMA. 2018; 
De T, Alarcon C, Hernandez W, Liko I, Cavallari LH, Duarte JD, Perera MA.
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摘要

Major warfarin-related bleeding occurs more frequently in African Americans than in other populations. Identification of potential genetic factors related to this adverse event may help identify at-risk patients.,To identify genetic factors associated with warfarin-related bleeding in patients of African descent at an international normalized ratio (INR) of less than 4.,A case-control genome-wide association study involving patients of African descent taking warfarin was conducted in a discovery cohort (University of Chicago [2009-2011] and the University of Illinois at Chicago [2002-2011]), and associations were confirmed in a replication cohort (University of Chicago [2015-2016]). Potential population stratif... More

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