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PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons.

Mol Brain. 2016; 
Zhu S, McGrath BC, Bai Y, Tang X, Cavener DR.
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Monoclonal Antibody Services Molecular Brain (2016) 9:87 Page 3 of 11 used in western blot analysis: monoclonal rabbit anti- PERK (Cell Signaling), monoclonal mouse anti-β-actin (GenScript). Get A Quote

摘要

PERK (EIF2AK3) is an ER-resident eIF2α kinase required for behavioral flexibility and metabotropic glutamate receptor-dependent long-term depression via its translational control. Motivated by the recent discoveries that PERK regulates Ca2+ dynamics in insulin-secreting β-cells underlying glucose-stimulated insulin secretion, and modulates Ca2+ signals-dependent working memory, we explored the role of PERK in regulating Gq protein-coupled Ca2+ dynamics in pyramidal neurons. We found that acute PERK inhibition by the use of a highly specific PERK inhibitor reduced the intracellular Ca2+ rise stimulated by the activation of acetylcholine, metabotropic glutamate and bradykinin-2 receptors in primary cortical neu... More

关键词

Ca2+; Gq protein-coupled receptor; PERK; Receptor-operated Ca2+ entry