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EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Neuro Oncol. 2019; 
Hübner JM,,, Müller T,, Papageorgiou DN, Mauermann M,, Krijgsveld J,, Russell RB,, Ellison DW, Pfister SM,,, Pajtler KW,,, Kool M,.
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ORF cDNA Clones/MolecularCloud CXorf67 peptide (VWHAVRMRASSPSPPGRFFLP) and the corresponding M to G variant peptide (VWHAVRGRASSPSPPGRFFLP) were synthesized by GenScript. Get A Quote

摘要

Posterior fossa A (PFA) ependymomas are one of 9 molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis, and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we reported overexpression of chromosome X open reading frame 67 (CXorf67) as a hallmark of PFA ependymoma and showed that CXorf67 can interact with enhancer of zeste homolog 2 (EZH2), thereby inhibiting polycomb repressive complex 2 (PRC2), but the mechanism of action remained unclear.,We performed mass spectrometry and peptide modeling analyses to identify the functional domain of CXorf67 responsible for binding and inhibition of EZH2... More

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