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Adropin induction of lipoprotein lipase expression in tilapia hepatocytes.

J Mol Endocrinol. 2016; 
Lian A, Wu K, Liu T, Jiang N, Jiang Q.
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摘要

The peptide hormone adropin plays a role in energy homeostasis. However, biological actions of adropin in non-mammalian species are still lacking. Using tilapia as a model, we examined the role of adropin in lipoprotein lipase (LPL) regulation in hepatocytes. To this end, the structural identity of tilapia adropin was established by 5'/3'-rapid amplification of cDNA ends (RACE). The transcripts of tilapia adropin were ubiquitously expressed in various tissues with the highest levels in the liver and hypothalamus. The prolonged fasting could elevate tilapia hepatic adropin gene expression, whereas no effect of fasting was observed on hypothalamic adropin gene levels. In primary cultures of tilapia hepatocytes, s... More

关键词

adropin; lipoprotein lipase; signal transduction pathway; tilapia hepatocytes