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An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.

Cell. 2018;

Roediger B, Lee Q, Tikoo S, Cobbin JCA, Henderson JM, Jormakka M, O'Rourke MB, Padula MP, Pinello N, Henry M, Wynne M, Santagostino SF, Brayton CF, Rasmussen L, Lisowski L, Tay SS, Harris DC, Bertram JF, Dowling JP, Bertolino P, Lai JH, Wu W, Bachovchin WW, Wong JJ, Gorrell MD, Shaban B, Holmes EC, Jolly CJ, Monette S, Weninger W.

Products/Services Used	Details	Operation
Custom DNA/RNA Oligos	SVJ129-Rag1tm1Bal/Arc Australian Resources Centre Product code: RAG1 N10 Mouse: Swiss Webster: Tac:SW Taconic Biosciences Cat# SW Mouse: Ubiquitin-eGFP: C57BL/6-Tg(UBC-GFP) 30Scha/J The Jackson Laboratory RRID: IMSR_JAX:004353 Oligonucleotides Primer: MKPV PCR Forward: TACATGGCCAAAG ATCCACA This paper N/A Primer: MKPV PCR Reverse: GTGGCAGTCACC CAGCTAAT This paper N/A Primer: MKPV qPCR Forward: GCAACACAACTG TAAATCGG This paper N/A Primer: MKPV qPCR Reverse: TGGATAATCGTG CCTAAACC This paper N/A Recombinant DNA DNA encoding residues 1-496 of VP1 Genscript Customised, this paper GST-VP1 This paper N/A pGEX-4T-1 GE Healthcare Cat# 28954549 pGEM-T Easy vectors Promega Cat# A1360 Software and Algorithms Adobe Photoshop CS6 Adobe https://www.... Recombinant GST-VP1 protein preparation DNA encoding residues 1–496 of VP1 was synthesized (Genscript, Piscataway, NJ, USA) and integrated into the glutathione S-trans- ferase (GST) fusion expression vector pGEX-4T-1 (GE Healthcare, Chicago, IL, USA).	Get A Quote

摘要

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of path... More