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Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

PLoS Genet. 2015; 
Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, Gignoux CR, Guethlein LA, Parham P.
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Recombinant Antibody Services Cell-surface expression of KIR2DL1 in transiently transfected HeLa Recombinant cDNA encoding the extracellular, stem, transmembrane and cytoplasmic domain (amino acids 1–336) of KIR2DL1 003 with an N-terminal 3X FLAG-tag was manufac- tured by Genscript (Piscataway, NJ) and cloned into the pcDNA3. Get A Quote

摘要

Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors (KIR) of Natural Killer (NK) cells and HLA class I ligands on the surface of tissue cells. Dominant interactions are between KIR2DL1 and the C2 epitope of HLA-C and between KIR2DL2/3 and the C1 epitope of HLA-C. KhoeSan hunter-gatherers of Southern Africa represent the earliest population divergence known and are the most genetically diverse indigenous people, qualities reflected in their KIR and HLA genes. Of the ten KhoeSan KIR2DL1 alleles, KIR2DL1*022 and KIR2DL1*026 likely originated in the KhoeSan, and later were transmitted at low frequency to the neigh... More

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