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Study on Aβ34 biology and detection in transgenic mice brains.

Neurobiol Aging. 2014; 
Caillava C, Ranaldi S, Lauritzen I, Bauer C, Fareh J, Abraham JD, Checler F.
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ORF cDNA Clones/MolecularCloud Membrane fraction (25 mg) was incubated at 37 C with 10 ng of Ab40 (Bachem, Bubendorf, Switzerland) or Ab34 (Genscript, Piscataway, NJ, USA) in Tris 10 mM pH 7. Get A Quote

摘要

The β-amyloid precursor protein undergoes cleavages by β- and γ-secretasses yielding amyloid-β peptides (Aβ) that accumulate in Alzheimer's disease. Subsequently, Aβ peptides are targets of additional truncations or endoproteolytic cleavages explaining the diversity of Aβ-related fragments recovered in cell media or pathologic human fluids. Here, we focused on Aβ1-34 (Aβ34) that has been detected both in vitro and in vivo and that derives from the hydrolysis of Aβ by β-secretase. We have obtained and fully characterized by immunologic and biochemical approaches, a polyclonal antibody that specifically recognizes the C-terminus of Aβx-34. We present immunohistochemical evidence for the presence of A... More

关键词

3xTg mice; Alzheimer's disease; Apoptosis; Aβ34; Degradation; HEK cells; Human brain; Neprilysin; Polyclonal