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Spatiotemporal Control of Viscoelasticity in Phototunable Hyaluronic Acid Hydrogels.

Biomacromolecules. 2019; 
Hui E, Gimeno KI, Guan G, Caliari SR.
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Nucleic Acid Purification & Analysis Soft (2 wt% NorHA) and stiff (6 wt% NorHA) hydrogel precursor solutions containing 1 mM thiolated RGD (GCGYGRGDSPG, Genscript) and dithiothreitol (DTT, thiol-norbornene ratios of 0. Get A Quote

摘要

Viscoelasticity has emerged as a critical regulator of cell behavior. However, there is an unmet need to develop biomaterials where viscoelasticity can be spatiotemporally controlled to mimic the dynamic and heterogeneous nature of tissue microenvironments. Toward this objective, we developed a modular hyaluronic acid hydrogel combining light-mediated covalent and supramolecular cross-linking to afford spatiotemporal control of network viscoelastic properties. Covalently cross-linked elastic hydrogels or viscoelastic hydrogels combining covalent and supramolecular interactions were fabricated to match healthy and fibrotic liver mechanics. LX-2 human hepatic stellate cells cultured on viscoelastic hydrogels disp... More

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