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Nanobodies as therapeutics: big opportunities for small antibodies.

Drug Discov Today. 2016; 
Steeland S, Vandenbroucke RE, Libert C.
Products/Services Used Details Operation
Antibody Modification and Purification Services GenScript Offers a comprehensive Nb service for research and therapeutic applications via selection and optimization of Nbs from immunized llamas of synthetic libraries Biotechnology company (USA) Get A Quote

摘要

Members of the Camelidae (including camels and llamas) produce, in addition to conventional antibodies (Ab), a unique type of Ab that lacks light chains. The variable antigen-binding domains derived from these Ab are named 'nanobodies' (Nbs). Nbs exert high specificity and affinity and, when properly selected, are more stable than conventional Ab. Furthermore, their toxicity and immunogenicity are both low. They are easy to produce and their modularity makes them amenable for the generation of multivalent complexes. In this review, we discuss how Nbs are being explored as therapeutics in many fields of medicine, including oncology, inflammatory, infectious and neurological diseases, and imaging. In addition, we... More

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