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Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin.

Horm Behav. 2019; 
Oppong-Damoah A, Zaman RU, D'Souza MJ, Murnane KS.
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Biochemicals … All the chemicals were of analytical grade and used as is without further modification. OT (GenScript USA, Piscataway, NJ) was dissolved in a mixture of 10% Tween-80 and saline and lightly vortexed for suspension. Nanoparticles … Get A Quote

摘要

The blood-brain barrier (BBB) limits the therapeutic use of large molecules as it prevents them from passively entering the brain following administration by conventional routes. It also limits the capacity of researchers to study the role of large molecules in behavior, as it often necessitates intracerebroventricular administration. Oxytocin is a large-molecule neuropeptide with pro-social behavioral effects and therapeutic promise for social-deficit disorders. Although preclinical and clinical studies are using intranasal delivery of oxytocin to improve brain bioavailability, it remains of interest to further improve the brain penetrance and duration of action of oxytocin, even with intranasal administration... More

关键词

Bioimaging; Blood-brain barrier; Cell culture; Nanotechnology; Oxytocin; Rabies virus glycoprotein; Social behavior