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Glycoprotein Hormone Receptor Knockdown Leads to Reduced Reproductive Success in Male Aedes aegypti.

Front Physiol. 2019; 
Rocco DA, Garcia ASG, Scudeler EL, Dos Santos DC,, Nóbrega RH, Paluzzi JV.
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Monoclonal Antibody Services … Primary antibodies included a custom affinity-purified rabbit polyclonal antibody raised against the A. aegypti LGR1 protein (0.5 μg ml -1 , Genscript Inc., Piscataway, NJ, United States) with specificity validated previously (Rocco et al., 2017), and a mouse monoclonal anti-γ … Get A Quote

摘要

Glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. The heterodimeric glycoprotein hormone GPA2/GPB5 and its receptor LGR1, constitute a recently discovered invertebrate neuroendocrine signaling system that remains to be functionally characterized. We previously reported that LGR1 is expressed in the testes of adult Aedes aegypti mosquitoes, where its immunoreactivity is particularly regionalized. Here, we show that LGR1 immunoreactivity is associated with the centriole adjunct of spermatids and is observed transiently during spermatogenesis in mosquitoes, where it may act to mediate the regulation of flagellar development. RNA interference... More

关键词

GPA2/GPB5; centriole adjunct; glycoprotein hormone receptor; leucine-rich repeat-containing G protein-coupled receptor 1 (LGR1); mosquito; spermatogenesis