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Dysregulation of the expression of HLA-DR, costimulatory molecule, and chemokine receptors on immune cells in children with autism.

Int Immunopharmacol. 2018; 
Ahmad SF, Ansari MA, Nadeem A, Bakheet SA, Al-Ayadhi LY, Alotaibi MR, Alhoshani AR, Al-Hosaini KA, Attia SM.
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Biochemicals … as previously described [12]. Quantitative analysis of mRNA expression was performed by RT-PCR. The primers used in this study were purchased from GenScript (Piscataway, USA). HLA-DR Forward: 5′-ACCGACTTTAAGAGGCGAGC … Get A Quote

摘要

Autism spectrum disorder (ASD) is a heterogeneous disorder diagnosed based on the severity of abnormalities in social skills. Several studies have acknowledged the presence of abnormal immune functions among individuals diagnosed with ASD. HLA-DR (human leukocyte antigen-antigen D related) has been shown to play a significant role in several inflammatory and neurological disorders; however, the role of HLA-DR signaling in ASD has not yet been fully clarified. In this study, we investigated the role of HLA-DR signaling in children with ASD. Flow cytometric analysis, using peripheral blood mononuclear cells (PBMCs), revealed the numbers of CD4+, CD8+, CD28+, CXCR4+, and CCR7+ expressing HLA-DR cells in typically ... More

关键词

Autism spectrum disorder; Cytokines; HLA-DR; Peripheral blood mononuclear cells; Transcription factors; Typically developing controls