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Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice.

Vaccine. 2019; 
Govasli ML, Diaz Y, Puntervoll P.
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Biochemicals … glycine, 25 mM sodium citrate, 0.1% (v/v) Tween 20 [pH 8.0]). 2.5. Immunizations. Immunizations and serum collection were performed by GenScript (Piscataway, NJ, USA). Five age-matched, 9 week old, female BALB/C mice were … Get A Quote

摘要

Enterotoxigenic Escherichia coli (ETEC) causes diarrhoea by secreting enterotoxins into the small intestine. Human ETEC strains may secrete any combination of three enterotoxins: the heat-labile toxin (LT) and the heat-stable toxins (ST), of which there are two variants, called human ST (STh) and porcine ST (STp). Strains expressing STh, either alone or in combination with LT and/or STp, are among the four most important diarrhoea-causing pathogens affecting children in low- and middle-income countries. ST is therefore an attractive target for ETEC vaccine development. To produce a safe ST-based vaccine, several challenges must be solved. ST must be rendered immunogenic and non-toxic, and antibodies elicited by... More

关键词

ETEC; Enterotoxin; Heat-stable toxin; ST; Subunit vaccine; Virus-like particles