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Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis.

Rev Soc Bras Med Trop. 2015;

Moura TM, Campos FS, Caierão J, Franco AC, Roehe PM, d'Azevedo PA, Frazzon J, Frazzon AP.

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摘要

Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.,Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.,A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .,Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.