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Fms-like tyrosine kinase 3 ligand is required for thymic dendritic cell generation from bone marrow-derived CD117⁺ hematopoietic progenitor cells.

Mol Med Rep. 2015; 
Xu Y, Jiang D, Hu Y, Li Y, Zhang X, Wang J, Wang Y.
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Biochemicals … All mice were bred in the animal facility of the Institute of Medical Biotechnology (Jiangsu, China) under pathogen-free conditions (18–22°C … Subsequently, the cDCs and pDCs were stimulated in vitro with CpG2006 (GenScript, Nanjing, China) for 24 h at 37°C, in a humidified … Get A Quote

摘要

Thymic dendritic cells (TDCs) are a type of dendritic cell (DC) in the thymus, which can enhance the proliferation of thymic T lymphocytes, regulate negative selection and induce central tolerance through autoantigen presentation. However, further investigations using TDCs has been restricted due to insufficient numbers. Therefore, an effective expansion method for TDCs in vitro is urgently required to further examine their biological characteristics. In the present study, a novel system was established using fetal thymus organ culture (FTOC) and a hanging drop culture system in the presence of fms‑like tyrosine kinase 3 ligand (Flt3L), termed the Flt3L/FTOC system. TDCs were successfully generated and expand... More

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