至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Methods for the expression, purification, and crystallization of histone deacetylase 6-inhibitor complexes.

Methods Enzymol. 2019; 
Osko JD, Christianson DW.
Products/Services Used Details Operation
Biochemicals … Two possible 2 3 4 5 6 7 8 9 commercial sources of this assay substrate are as follows: a GenScript Biotech Corp: $39857 for 250–290 mg; average unit cost¼ $1484/mg b Enzo Life Sciences, Inc: $20100 for $040 mg; average unit cost¼ $ $500/mg 11 … Get A Quote

摘要

Histone deacetylase (HDAC) isozymes modulate numerous regulatory signals and pathways in biological systems, hence serving as targets for drug design. For example, HDAC6 is the cytosolic tubulin deacetylase and its inhibition compromises microtubule dynamics, leading to cancer cell cycle arrest and apoptosis. The design of inhibitors that selectively target HDAC6 is desirable to avoid side effects resulting from the inhibition of off-target HDACs. High resolution X-ray crystal structures of HDAC6 have accelerated structure-based approaches to drug design targeting HDAC6. Crystal structure analysis reveals that the tubulin deacetylase domain of human HDAC6 (catalytic domain 2, also known as CD2) is very similar ... More

关键词

Drug design; Epigenetics; Protein crystallography; Tubulin; Zinc enzyme