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Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants.

Acta Biomater. 2019; 
Terkawi MA, Kadoya K, Takahashi D, Tian Y, Hamasaki M, Matsumae G, Alhasan H, Elmorsy S, Uetsuki K, Onodera T, Takahata M, Iwasaki N.
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Nucleic Acid Purification & Analysis … Eogelk-SA-H160, Osaka, Japan) [15] Endotoxin levels in the prepared samples were below the detection limit (0015 EU/ml) of ToxinSensor Single Test Kit (Genscript, Piscataway, NJ, USA) Particle sizes were analyzed by … Get A Quote

摘要

Vitamin E-blended ultra-high molecular weight polyethylene (VE-UHMWPE) is a newly introduced material for prosthetic components that has proven a better mechanical performance with lesser adverse cellular responses than conventional polyethylene in experimental animal models. However, the mechanisms by which VE-UHMWPE particles trigger a reduced osteolytic activity are unclear and remain to be investigated. Therefore, the current study aims at exploring a possible anti-osteolytic mechanism associated with VE-UHMWPE particles. Transcriptional profiling and bioinformatic analyses of human macrophages stimulated by VE-UHMWPE particles revealed a distinct transcriptional program from macrophages stimulated with UHM... More

关键词

IL-27; Implant particles; Macrophages; Osteolysis; Osteolysis mouse model; Transcriptional profiling