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Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.

Acta Biomater. 2019; 
Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ.
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Nucleic Acid Purification & Analysis … Four hydrogels were implanted per mouse, one over each shoulder and one over each hip, and incisions were closed with surgical staples Prior to implantation, hydrogels were confirmed endotoxin-free (Limulus Amebocyte Lysate test kit, GenScript) … Get A Quote

摘要

Synthetic hydrogels, such as poly(ethylene glycol) (PEG), are promising for a range of in vivo applications. However, like all non-biological biomaterials, synthetic hydrogels including PEG elicit a foreign body response (FBR). The FBR is thought to be initiated by adsorbed protein that is recognized by and subsequently activates inflammatory cells, notably macrophages, and culminates with fibrotic encapsulation. However, the molecular mechanisms that drive the FBR are not well understood. Toll-like receptors (TLRs) are key receptors that recognize pathogens, but also recognize altered host proteins that display damage-associated molecular patterns (DAMPs). Thus TLRs may play a role in the FBR. Here, we investi... More

关键词

Fibrous encapsulation; Foreign body response; Macrophage; MyD88; PEG hydrogel