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TGFβ1 mimetic peptide modulates immune response to grass pollen allergens in mice.

Allergy. 2019; 
Araujo GR, Aglas L, Vaz ER, Machado Y, Huber S, Himly M, Duschl A, Goulart LR, Ferreira F.
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Biochemicals … 12- myristate 13-acetate (PMA) (Jurkat cells; Sigma-Aldrich, Darmstadt, Germany) plus 500 ng/ml ionomycin (Sigma-Aldrich), or 20 ng/ml TNF-α (A549 cells; GenScript, Piscataway, NJ, USA) for 24 h at 37°C and 5% CO2 Supernatant … Get A Quote

摘要

Transforming growth factor β1 (TGFβ1) is a cytokine that exerts immunosuppressive functions, as reflected by its ability to induce regulatory T (Treg) cell differentiation and inhibit Th1 and Th2 responses. Hence, peptides that mimic the active core domain of TGFβ1 may be promising candidates for modulation of the allergic response. This study aimed to investigate a synthetic TGFβ1 mimetic peptide (TGFβ1-mim) for its ability to modulate the immune response during allergic sensitization to grass pollen allergens.,The in vitro action of TGFβ1-mim was evaluated in human lung epithelial cells, Jurkat cells, and rat basophilic leukemia cells. The in vivo action was evaluated in a murine model of Phl p 5 allerg... More

关键词

TGFβ1; allergic sensitization; grass pollen allergy; immune regulation; immunotherapy