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Co-Administration Of iRGD Enhances Tumor-Targeted Delivery And Anti-Tumor Effects Of Paclitaxel-Loaded PLGA Nanoparticles For Colorectal Cancer Treatment.

Int J Nanomedicine. 2019; 
Zhong Y, Su T, Shi Q, Feng Y, Tao Z, Huang Q, Li L, Hu L, Li S, Tan H, Liu S, Yang H.
Products/Services Used Details Operation
Biochemicals … (Jinan, China) PTX was purchased from Dalian Melone Biomart Co, Ltd, and iRGD (CRGDRGPDC) was provided by Genscript Co, Ltd (Guilin, China) Coumarin-6 and polyvinylalcohol (PVA) were purchased from Sigma-Aldrich (St Louis, MO, USA) … Get A Quote

摘要

Nanoparticles exhibit great promise for improving the solubility and tissue-specific distribution of chemotherapeutic agents; however, the passive and highly variable enhanced permeability and retention (EPR) effects observed in tumors frequently leads to insufficient delivery of nanodrugs into tumors. The tumor-penetrating peptide iRGD can actively enhance tumor-selective delivery of nanoparticles into tumors by binding to integrin and interacting with tissue-penetrating receptor neuropilin-1.,To improve colorectal cancer treatment, in this study, we prepared a paclitaxel (PTX)-loaded PLGA nanoparticle (PLGA-PTX) and evaluated its tumor-targeting and antitumor activity by co-administration with iRGD.,Compared ... More

关键词

colorectal cancer; iRGD; nanoparticle; paclitaxel; tumor penetrating peptide; tumor vasculature