| Products/Services Used | Details | Operation |
|---|---|---|
| Gene Synthesis | … also elicit transgene expression in vivo Methods Plasmid construction The ITR sequences from AAV serotypes 1‐4 & 6‐7 sequences were ordered from Genscript with unique restriction enzyme sites flanking the sequences for downstream cloning These … | Get A Quote |
Gene transfer vectors based on adeno-associated virus (AAV) are showing exciting therapeutic promise in early phase clinical trials. The ability to cross-package the prototypic AAV2 vector genome into different capsids is a powerful way of conferring novel tropism and biology, with evolving capsid engineering technologies and directed evolution approaches further enhancing the utility and flexibility of these vectors. Novel properties of specific capsids show unpredictable species and cell-type specificity. Therefore, full realisation of the therapeutic potential of AAV vectors requires the development of more therapeutically predictive preclinical methods for evaluating capsid performance. This will strongly c... More
