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Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes.

Toxicol Ind Health. 2016; 
Uygur R, Aktas C, Caglar V, Uygur E, Erdogan H, Ozen OA.
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摘要

This study aimed to investigate the protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. A total of 27 male rats were divided into 3 groups: control (saline: 5 ml kg(-1) day(-1), intragastrically), arsenic (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically), and arsenic + melatonin (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically and melatonin: 25 mg kg(-1) day(-1), intraperitoneally) group. At the end of 30 days, the rats were killed under anesthesia. Histopathological examination showed that testicular injury mediated by arsenic was ameliorated by the administration of melatonin. The number of apoptotic germ cell was increased, and... More

关键词

Arsenic; apoptosis; melatonin; oxidative stress; testis