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Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA …

Cell Death Dis. 2018; 
Chen CC,  Chen CY,  Ueng SH,  Hsueh C,  Yeh CT,  Ho JY,  Chou LF,  Wang TH
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ORF cDNA Clones/MolecularCloud pCDNA3.1-RAD51-AS1, a CMV-based expression plasmid containing lncRNA-RAD51-AS1, and pCMV-FLAG-RAD51 plasmid were constructed by GenScript Co. (Piscataway, NJ, USA). Get A Quote

摘要

Corylin, a biologically active agent extracted from Psoralea corylifolia L. (Fabaceae), promotes bone differentiation and inhibits inflammation. Currently, few reports have addressed the biological functions that are regulated by corylin, and to date, no studies have investigated its antitumor activity. In this study, we used cell functional assays to analyze the antitumor activity of corylin in hepatocellular carcinoma (HCC). Furthermore, whole-transcriptome assays were performed to identify the downstream genes that were regulated by corylin, and gain-of-function and loss-of-function experiments were conducted to examine the regulatory roles of the above genes. We found that corylin significantly inhibited th... More

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