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RNA interference knockdown of aminopeptidase N genes decrease the susceptibility of Chilo suppressalis larvae to Cry1Ab/Cry1Ac and Cry1Ca-expressing transgenic rice

J Invertebr Pathol. 2016;

Qiu L, Fan J, Zhang B, Liu L, Wang X, Lei C, Lin Y, Ma W.

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DNA Sequencing	… The control treatment was EGFP dsRNA produced by a pET2P/EGFP recombinant plasmid. Correct inserts of the recombinant plasmids were confirmed by sequencing conducted by the Genscript Biology Company, Nanjing, China …	Get A Quote

摘要

Transgenic rice expressing Bacillus thuringiensis (Bt) Cry toxins are resistant to lepidopteran pests, such as Chilo suppressalis, a major insect pest of rice in Asia. Understanding how these toxins interact with their hosts is crucial to understanding their insecticidal action. In this study, knockdown of two aminopeptidase N genes (APN1 and APN2) by RNA interference resulted in decreased susceptibility of C. suppressalis larvae to the Bt rice varieties TT51 (Cry1Ab and Cry1Ac fusion genes) and T1C-19 (Cry1Ca), but not T2A-1 (Cry2Aa). This suggests that APN1 and APN2 are receptors for Cry1A and Cry1C toxins in C. suppressalis.,Copyright © 2017 Elsevier Inc. All rights reserved.