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| Molecular Biology Tools | … The primers were designed using Primer Premier 5 (GenScript Real-time PCR Primer Design, https://www.genscript.com/ssl-bin/app/primer) and DNAStar software (DNAStar company, Madison, WI, USA), and subjected to BLAST analysis (NCBI) … | Get A Quote |
Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parki... More
