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Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation

Cell Commun Signal. 2020; 
Xu A, Yang Y, Shao Y, Wu M, Sun Y.
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ORF cDNA Clones/MolecularCloud In short, cDNA templates were mixed with primers (Genscript, Nanjing, China), Sybr Green (Sigma-Aldrich, St. Get A Quote

摘要

Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bone mass homeostasis. Our group prior demonstrated that activation of CNR2 signaling promoted osteogenic differentiation of bone marrow derived mesenchymal stem cells in vitro. Autophagy is reported to participate in osteoblastic differentiation. Whether autophagy is regulated by CNR2-mediated cannabinoid signaling is unknown, and how the autophagy-CNR2 interaction affects osteoblastic differentiation requires further elucidation.,hFOB 1.19 osteoblasts were treated with CNR2 agonists HU308 (5, 10, 25, 50 or... More

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