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Integration of a multi-step heterologous pathway in Saccharomyces cerevisiae for the production of abscisic acid

Microb Cell Fact. 2019; 
Otto M, Teixeira PG, Vizcaino MI, David F, Siewers V.
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Molecular Biology Tools cinerea strain ATCC58025 were ordered from Genscript (https ://www. Get A Quote

摘要

The sesquiterpenoid abscisic acid (ABA) is mostly known for regulating developmental processes and abiotic stress responses in higher plants. Recent studies show that ABA also exhibits a variety of pharmacological activities. Affordable and sustainable production will be required to utilize the compound in agriculture and as a potential pharmaceutical. Saccharomyces cerevisiae is an established workhorse for the biotechnological production of chemicals. In this study, we constructed and characterised an ABA-producing S. cerevisiae strain using the ABA biosynthetic pathway from Botrytis cinerea.,Expression of the B. cinerea genes bcaba1, bcaba2, bcaba3 and bcaba4 was sufficient to establish ABA production in the... More

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