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Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome)

Sci Rep. 2019; 
Walsh DM, Hokenstad AN, Chen J, Sung J, , Jenkins GD, Chia N, Nelson H, Mariani A, Walther-Antonio MRS,
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Molecular Biology Tools Specifc 16S rDNA primers and probes for P. somerae and A. vaginae were designed using GenScript Real-time PCR (Taqman) Primer Design online sofware (https://www.genscript. com/tools/real-time-pcr-tagman-primer-design-tool). Get A Quote

摘要

Incidence rates for endometrial cancer (EC) are rising, particularly in postmenopausal and obese women. Previously, we showed that the uterine and vaginal microbiome distinguishes patients with EC from those without. Here, we sought to examine the impact of patient factors (such as menopause status, body mass index, and vaginal pH) in the microbiome in the absence of EC and how these might contribute to the microbiome signature in EC. We find that each factor independently alters the microbiome and identified postmenopausal status as the main driver of a polymicrobial network associated with EC (ECbiome). We identified Porphyromas somerae presence as the most predictive microbial marker of EC and we confirm thi... More

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