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Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever

Diagnosis of Enteric Fever. 2020; 
Shailendra Kumar,a Ariana Nodoushani,b Farhana Khanam,c Alyssa T. DeCruz,a Paul Lambotte,a Robert Scott,a Isaac I. Bogoch,d Krista Vaidya,e Stephen B. Calderwood,b,f,g Taufiqur R. Bhuiyan,c Javan Esfandiari,a Edward T. Ryan,b,f,h Firdausi Qadri,c Jason R. Andrews,i Richelle C. Charlesb,f
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摘要

There is a critical need for an improved rapid diagnostic for enteric fever. We have previously demonstrated that serum IgA responses targeting Salmonella enterica serovar Typhi hemolysin E (HlyE) and lipopolysaccharide (LPS) are able to discriminate patients with acute typhoid from healthy controls in areas where enteric fever is endemic (healthy endemic controls) and from patients with other bacterial infections. We now have data demonstrating that IgA antibody responses against these antigens also work well for identifying patients with acute S. Paratyphi A infection. To develop a test for acute enteric fever detection, we have adapted a point-of-care immunochromatographic dual-path platform technology (DPP)... More

关键词

S. Paratyphi A, S. Typhi, Salmonella, diagnostic, enteric fever, paratyphoid, point-of-care, typhoid