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Testing for SARS-CoV-2 (COVID-19): a systematic review and clinical guide to molecular and serological in-vitro diagnostic assays

Pre-proof. 2020-05; 
Antonio La Marca, M.D., Ph. D.a, Martina Capuzzo, M.D.a, Tiziana Paglia, M.D.b, Laura RoliM.Sc.c, Tommaso Trenti, M.D.c, Scott M Nelson, M.D., Ph.D.d,e,f
Products/Services Used Details Operation
Catalog Antibody Ozturk T et al.,2020 Cross sectional 148 subjects 32 RNA positive patients, 116 controls USA Comme rcial assay ELISA by GenScript The complex relationship between antibody levels, disease severity, and time since symptom onset, caution is needed in using serologic assayto inform public88.9% 92.3% NA NA Get A Quote

摘要

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated Coronavirusdisease 2019 (COVID-19) pandemic has demanded rapid upscaling of in-vitro diagnostic assays toenable mass screening and testing of high-risk groups, and simultaneous ascertainment of robustdata on past SARS-CoV-2 exposure at an individual and population level. To meet the exponentialdemand in testing, there has been an accelerated development of both molecular and serologicalassays across a plethora of platforms. In the present review, we discuss the current literature onthese modalities including the nucleic acid amplification tests, direct viral antigen tests and therapidly expanding laboratory based and point of ca... More

关键词

SARS-CoV-2, COVID-19, diagnostic test, serology, antibody testing