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Structural characterization of vaccinia-related kinase 1 (VRK1), a histone mitotic kinase

dr.ntu.edu.. 2019; 
Ngow, Yeen Shian
Products/Services Used Details Operation
Biochemicals The VRK1 crystallization construct (VRK1cryst) was purchased from GenScript, USA. Get A Quote

摘要

The human vaccinia-related kinase 1 (VRK1), is a mitotic kinase, involved in cell division regulation and carcinogenesis. VRK1 phosphorylates the histone H3 at Thr3 and Ser10, which is a critical event for initiating chromosome condensation during mitosis. The deregulation of VRK1 can affect chromatin architecture and remodeling during mitosis, which could result in aneuploidy and genome instability, leading to cancer. Recent studies have shown that high levels of VRK1 is directly correlated to poor clinical outcomes in breast cancer patients, apart from colorectal, prostate and lung cancers among others. Hence, inhibiting VRK1 is considered a viable approach toward developing cancer drugs. VRK1 can be targeted... More

关键词

DRNTU::Science::Biological sciences