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Mutually Exclusive CBC and CBC-ARS2 Containing Complexes Coordinate the Fate of RNA Polymerase II Transcripts

heiDOK. 2017; 
Schulze, Wiebke Manuela
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摘要

RNA Polymerase II (Pol II) transcripts comprise many different RNA classes that undergo co-transcriptionally complex maturation processes including the addition of a 5’ cap structure, removal of introns via splicing, 3’ end processing and the assembly into transport competent ribonucleoprotein particles. How all these processes are coordinated, regulated and quality controlled, is a central question in RNA biology. One of the processes all Pol II transcripts have in common is the addition of a cap structure to the 5’ end. This 5’ cap structure is immediately bound by the heterodimeric cap binding complex CBC comprising subunit CBP80 and the cap binding subunit CBP20. The cap structure as well as CBC are... More

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