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A Whole Genome Re-Sequencing Based GWA Analysis Reveals Candidate Genes Associated with Ivermectin Resistance in

Genes (Basel). 2020-03-01; 
Sawar Khan, Ayesha Nisar, Jianqi Yuan, Xiaoping Luo, Xueqin Dou, Fei Liu, Xiaochao Zhao, Junyan Li, Habib Ahmad, Sardar Azhar Mehmood, Xingang Feng
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ORF cDNA Clones/MolecularCloud … Double-stranded siRNA specifically targeting candidate genes (HCON_00143950 and HCON_00155510) were designed using GenScript siRNA Target Finder tool (https://www. genscript.com/tools/sirna-target-finder) by looking/searching for pattern “AAN19” in the ORF of … Get A Quote

摘要

The most important and broad-spectrum drug used to control the parasitic worms to date is ivermectin (IVM). Resistance against IVM has emerged in parasites, and preserving its efficacy is now becoming a serious issue. The parasitic nematode (Rudolphi, 1803) is economically an important parasite of small ruminants across the globe, which has a successful track record in IVM resistance. There are growing evidences regarding the multigenic nature of IVM resistance, and although some genes have been proposed as candidates of IVM resistance using lower magnification of genome, the genetic basis of IVM resistance still remains poorly resolved. Using the full magnification of genome, we herein applied a population ge... More

关键词

Haemonchus contortus, RNAi, drug resistance, functional validation, ivermectin, larvae culture, population genomics