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Group I Metabotropic Glutamate Receptor Interacting Proteins: Fine-Tuning Receptor Functions in Health and Disease

Curr Neuropharmacol. 2016; 
Magdalena Kalinowska, Anna Francesconi
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Monoclonal Antibody Services … EXPERIMENTAL PROCEDURES Antibodies, reagents. - The following antibodies were used: goat polyclonal anti-GAPDH (GenScript), chicken polyclonal anti-MAP2 (EnCor Biotech); rabbit monoclonal antibodies anti-Actn4, anti-Actn1 and anti-mGlu5 (Epitomics); rabbit … Get A Quote

摘要

Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell- or pathway-specific modulation to fine-tune receptor function, thus representing a potential target for pharmacological i... More

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