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EHFPI: a database and analysis resource of essential host factors for pathogenic infection

Nucleic Acids Res. 2014-11-01; 
Yang Liu, Dafei Xie, Lu Han, Hui Bai, Fei Li, Shengqi Wang, Xiaochen Bo
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摘要

High-throughput screening and computational technology has greatly changed the face of microbiology in better understanding pathogen-host interactions. Genome-wide RNA interference (RNAi) screens have given rise to a new class of host genes designated as Essential Host Factors (EHFs), whose knockdown effects significantly influence pathogenic infections. Therefore, we present the first release of a manually-curated bioinformatics database and analysis resource EHFPI (Essential Host Factors for Pathogenic Infection, http://biotech.bmi.ac.cn/ehfpi). EHFPI captures detailed article, screen, pathogen and phenotype annotation information for a total of 4634 EHF genes of 25 clinically important pathogenic species. No... More

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