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Protection against lethal vaccinia virus infection in mice using an siRNA targeting the A5R gene

Antivir Ther. 2016-01-01; 
Dongjoon Seo, Na Young Kim, Jin Ah Lee, Kang Rok Han, Gyeung Haeng Hur, Jai Myung Yang, Sungho Shin
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Molecular Biology Tools … Web-based siRNA design tools from the Ambion (Austin, TX, USA), GenScript (Piscataway, NJ, USA) and Dharmacon (Chicago, IL, USA) web- sites were used to design the … Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque … Get A Quote

摘要

background: Although the World Health Organization has declared the eradication of smallpox in 1980, the fear of its potential use in bioterrorism has become a reality. Since the effectiveness of current vaccines and antiviral drugs is limited, development of new therapeutic strategies is needed. In this study, we investigated small interfering RNA (siRNA) as a therapeutic approach for preventing and treating smallpox infection. methods: Eight siRNA sequences were designed and evaluated for antiviral activity against vaccinia virus (VACV) in vitro and in vivo. results: Of eight siRNAs, A5R1 siRNA targeted the A5R gene and reduced VACV replication in cell culture by up to 85% at 100 nM concentration without indu... More

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