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Selenium-Doped Carbon Quantum Dots Act as Broad-Spectrum Antioxidants for Acute Kidney Injury Management

Adv Sci (Weinh). 2020-04-01; 
Zachary T Rosenkrans, Tuanwei Sun, Dawei Jiang, Weiyu Chen, Todd E Barnhart, Ziyi Zhang, Carolina A Ferreira, Xudong Wang, Jonathan W Engle, Peng Huang, Weibo Cai
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摘要

The manifestation of acute kidney injury (AKI) is associated with poor patient outcomes, with treatment options limited to hydration or renal replacement therapies. The onset of AKI is often associated with a surfeit of reactive oxygen species. Here, it is shown that selenium-doped carbon quantum dots (SeCQDs) have broad-spectrum antioxidant properties and prominent renal accumulation in both healthy and AKI mice. Due to these properties, SeCQDs treat or prevent two clinically relevant cases of AKI induced in murine models by either rhabdomyolysis or cisplatin using only 1 or 50 µg per mouse, respectively. The attenuation of AKI in both models is confirmed by blood serum measurements, kidney tissue staining, ... More

关键词

acute kidney injury, carbon quantum dots, cisplatin, nanomedicine, positron emission tomography, rhabdomyolysis, selenium