至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Mammalian Target of Rapamycin 2 (MTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through Glutamine: Fructose-6-Phosphate Aminotransferase 1 (GFAT1)

Cell Mol Neurobiol. 2019-02-01; 
Bo Liu, Ze-Bin Huang, Xin Chen, Yi-Xiang See, Zi-Kai Chen, Huan-Kai Yao
Products/Services Used Details Operation
Recombinant Antibody Expression … com); recombinant human GFPT1 protein and GFPT1 cDNA clone from Sino Biological (Beijing, China; http://jp.sinobiological.com); and human, mouse, rat, zebra fish, and chicken GFPT1 and GFPT2 cDNA clones from GenScript (Piscataway, NJ; http://www.genscript.com) … Get A Quote

摘要

Glucose and glutamine are two essential ingredients for cell growth. Glycolysis and glutaminolysis can be linked by glutamine: fructose-6-phosphate aminotransferase (GFAT, composed of GFAT1 and GFAT2) that catalyzes the synthesis of glucosamine-6-phosphate and glutamate by using fructose-6-phosphate and glutamine as substrates. The role of mammalian target of rapamycin (MTOR, composed of MTOR1 and MTOR2) in regulating glycolysis has been explored in human cancer cells. However, whether MTOR can interact with GFAT to regulate glucosamine-6-phosphate is poorly understood. In this study, we report that GFAT1 is essential to maintain the malignant features of GBM cells. And MTOR2 rather than MTOR1 plays a robust ro... More

关键词

GBM, GFAT1, Glutaminolysis, Glycolysis, MTOR2