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Comparison of the reaction of methylglyoxal (MGO) with murine and human amyloid beta (Aβ): Insights into a mechanism of Alzheimer's disease (AD)

Biochem Biophys Res Commun. 2020;

Sydney O Shuster, Sebastian M Fica-Contreras, Jake S Hedges, Nathaniel J Henning, Sunhee Choi

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Mutagenesis Services	… 2. Materials and methods. Chemicals Human Aβ (1-40) and murine Aβ (1-40) were purchased from Anaspec and Genscript. All mutants of Aβ were purchased from Lifetein. All other chemicals were purchased from Sigma Aldrich …	Get A Quote

摘要

Reacted with methylglyoxal (MGO), murine Aβ(1-40) (mAβ) produced significantly less superoxide anion (O) compared to human Aβ (hAβ). The reactions of MGO with mAβ(R13H), hAβ(H13F), N-acetyl-l-lysine, and N-acetyl-l-arginine implied that the lack of His13 in mAβ prohibits its Lys16 residue from reacting to produce cross-linked reaction products and O. Our results suggest that murine brains are under less oxidative stress than human brains, which may be one of the reasons why rodents do not develop AD-like symptoms, and which provides further insight into a chemical mechanism for the development of AD in humans.