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TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Front Physiol. 2020-11; 
Adam Hagg, Swati Kharoud, Georgia Goodchild, Craig A Goodman, Justin L Chen, Rachel E Thomson, Hongwei Qian, Paul Gregorevic, Craig A Harrison, Kelly L Walton
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Mammalian Expression … mammalian vector comprising the full length human TMEPAI sequence (reference sequence {"type":"entrez-nucleotide","attrs":{"text":"NM_020182.4","term_id":"364023807","term_text":" NM_020182.4"}}NM_020182.4) was obtained from GenScript (New Jersey, United States) … Get A Quote

摘要

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy. However, clinical translation of these extracellular approaches targeting myostatin and activin has been hindered by the challenges of achieving efficacy without potential effects in other tissues. Toward the goal of developing tissue-specific myostatin/activin interventions, we explored the ability of transmembrane prostate androgen-induced (TMEPAI), an inhibitor of transforming growth factor-β (TGF-β1)-mediated SMAD... More

关键词

Gdf11, PMEPA1, TMEPAI, activin, cachexia, muscle, myostatin