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Early preclinical screening using zebrafish () reveals the safety of the candidate anti-inflammatory therapeutic agent P

Toxicol Rep. 2020-12; 
João Batista-Filho, Maria Alice Pimentel Falcão, Adolfo Luis Almeida Maleski, Amanda Beatriz Silva Soares, Leticia Balan-Lima, Geonildo Rodrigo Disner, Carla Lima, Monica Lopes-Ferreira
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Plasmids for SARS-CoV-2 Detection and Research … to a patent application in several countries and currently is patented in Europe (EP2046815B1) Mexico (MX300187), United States (US8304382B2) Canada … TnP trifluoroacetate compound synthetized in solid phase was purchased from GenScript (#P13821401, 97.3% of purity) … Get A Quote

摘要

The patented anti-inflammatory peptide P had its effectiveness recently confirmed in a murine model of multiple sclerosis and asthma. In this work, the safety of the P was evaluated in investigative toxicology tests using zebrafish () as a model. We conducted the OECD #236 test to investigate effects of the P on the survival, hatching performance, and morphological formation of zebrafish embryos. After determining these endpoints, morphometric analysis termination of locomotion eartbeat rate in zebrafish larvae were evaluated to identify adverse effects such as neurotoxicity and cardiotoxicity. The results highlight a wide therapeutic index for P with non-lethal and safe doses rom 1 nM to 10 μM, without c... More

关键词

Drug safety, Preclinical analysis, TnP peptide, Toxicology assessments, Zebrafish