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YSIRK-G/S-directed translocation is required for to deliver diverse cell wall anchoring effectors contributing to bacterial pathogenicity

Virulence. 2020; 
Qiankun Bai, Jiale Ma, Ze Zhang, Xiaojun Zhong, Zihao Pan, Yinchu Zhu, Yue Zhang, Zongfu Wu, Guangjin Liu, Huochun Yao
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Recombinant Antibody Expression … three point-mutations (ASARA) in YSIRK-G/S encoding sequence. DNA sequencing was performed by Genscript Biotechnology Co Ltd (Nanjing, China). Purification of recombinant protein and preparation of polyclonal antibody … Get A Quote

摘要

The serotype 2 (SS2) is a significant zoonotic pathogen that is responsible for various swine diseases, even causing cytokine storms of Streptococcal toxic shock-like syndromes amongst human. Cell wall anchoring proteins with a C-terminal LPxTG are considered to play vital roles during SS2 infection; however, their exporting mechanism across cytoplasmic membranes has remained vague. This study found that YSIRK-G/S was involved in the exportation of LPxTG-anchoring virulence factors MRP and SspA in virulent SS2 strain ZY05719. The whole-genome analysis indicated that diverse LPxTG proteins fused with an N-terminal YSIRK-G/S motif are encoded in strain ZY05719. Two novel LPxTG proteins SspB and YzpA were verifie... More

关键词

LPxTG motif, YSIRK-G/S motif, cell wall anchoring effector, pathogenicity