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Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Neurobiol Dis. 2020-11; 
Qian Wu, Yang Bai, Wei Li, Erin E Congdon, Wenke Liu, Yan Lin, Changyi Ji, Wen-Biao Gan, Einar M Sigurdsson
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Monoclonal Antibody Services … 2.3. Antibodies and intravenous injections. Monoclonal antibody (mAb) 4E6G7 (referred to as 4E6) was purified from our hybridomas by Genscript (Paramus, NJ). IgG1κ (referred to as IgG) of the same isotype as the tau mAb 4E6 served as control (eBioscience, 16–4714) … Get A Quote

摘要

Perturbed neuronal Ca homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models. In this study, we injected AAV to express Ca indicator in layer II/III motor cortex neurons and measured neuronal Ca activity by two photon imaging in awake transgenic JNPL3 tauopathy and wild-type mice. Various biochemical measurements were conducted in postmortem mouse brains for mechanistic insight and a group of animals received two intravenous injections of a tau monoclonal antibody spaced by four days to test whether the Ca dyshomeostasis was related to pathological tau protein. Under running conditions,... More

关键词

Alzheimer's disease, Antibody, Ca(2+), Frontotemporal dementia, Mice, Tau, Two-photon imaging