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Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway

Immunopharmacol Immunotoxicol. 2020-11; 
Xiao-Sha Li, Xue-Yong Tang, Wei Su, Xin Li
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Custom DNA/RNA Oligos … Briefly, siRNA oligos were designed and synthesized by GenScript (NanJing, China). Melanocytes … method. GAPDH was used as internal control. The following primer sets were designed and synthesized by GenScript (NanJing, China) … Get A Quote

摘要

background: Vitiligo is the most common type of depigmented skin disease. Cellular oxidative stress caused by reactive oxygen species (ROS) has been implicated in the pathogenesis of vitiligo. Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway plays an important role in melanocytes against hydrogen peroxide (HO) induced oxidative stress. In addition, vitexin may protect vitiligo by inhibiting oxidative stress and inflammation. objective: In the present study, we aimed to investigate the antioxidant effect of vitexin-activated mitogen-activated protein kinase (MAPK)-Nrf2/ARE axis in vitiligo. methods: MTT assay identified cell viability of human melanocyte PIG1. Cell apoptosis w... More

关键词

MAPK-Nrf2/ARE, Nrf2/ARE signaling pathway, Vitiligo, oxidative stress, vitexin