Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug resistant bacteria. Here, we used a combined approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Minimal Inhibitory Concentration (MIC) values increased from 1 μg/ml to 1024 μg/ml. We report here new family of potential chromosomal fosfomycin resistance genes named .
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug resistant bacteria. Here, we used a combined approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Minimal Inhibitory Concentration (MIC) values increased from 1 μg/ml to 1024 μg/ml. We report here new family of potential chromosomal fosfomycin resistance genes named .
