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Hsa_circRNA_102610 upregulation in Crohn's disease promotes transforming growth factor-β1-induced epithelial-mesenchymal transition sponging of hsa-miR-130a-3p

World J Gastroenterol. 2020; 
Juan Yin, Yu-Lan Ye, Tong Hu, Li-Juan Xu, Li-Ping Zhang, Ru-Ning Ji, Ping Li, Qian Chen, Jian-Yun Zhu, Zhi Pang
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GenParts™ DNA Fragments … A fragment containing a total of 273 bp of hsa_circRNA_102610 including the hsa-miR-130a- 3p response element was synthesized (GenScript, Nanjing, Jiangsu Province, China) and cloned into the plasmid psiCHECK-2 (Promega, Madison, WI, United States) … Get A Quote

摘要

background: The incidence of inflammatory bowel disease, a chronic intestinal inflammatory disorder that includes Crohn's disease (CD) and ulcerative colitis, is rising. Circular RNAs are considered valuable diagnostic biomarkers for CD. Current evidence supports the views that epithelial-mesenchymal transition (EMT) plays an important role in CD pathogenesis, and that hsa-miR-130a-3p can inhibit transforming growth factor-β1 (TGF-β1)-induced EMT. Our previous study revealed that hsa_circRNA_102610 was upregulated in CD patients. Moreover, we predicted an interaction between hsa_circRNA_102610 and hsa-miR-130a-3p. Thus, we hypothesized that hsa_circRNA_102610 may play roles in the proliferation and EMT of int... More

关键词

Crohn’s disease, Epithelial-mesenchymal transition, Hsa-miR-130a-3p, Hsa_circRNA_102610, Mothers against decapentaplegic homolog 4, Transforming growth factor-β1