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Biological activities of a recombinant fortilin from Fenneropenaeus merguiensis

PLoS ONE. 2020; 
Ureporn Kedjarune-Leggat, Uraipan Saetan, Anchana Khongsaengkaeo, Sudarat Suwannarat, Panchalika Deachamag, Monwadee Wonglapsuwan, Rawiwan Pornprasit, Wanwisa Thongkamwitoon, Parujee Phumklai, Jirapan Chaichanan, Wilaiwan Chotigeat
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GenParts™ DNA Fragments … After digestion and purification, all fragments were subsequently cloned into the pET29a+ vector (GenScript) and further verified by sequencing. The rFm-Fortilin (F12, F2, and F23) plasmids were transformed in E. coli BL21(DE3) … Get A Quote

摘要

Human Fortilin, an antiapoptotic protein, has also been implicated in several diseases; however, several potential uses of fortilin have also been proposed. Bearing the implications of fortilin in mind, fortilin analog, which has no complication with diseases, is required. Since a recombinant full-length fortilin from Fenneropenaeus merguiensis (rFm-Fortilin (FL)) reported only 44% (3e-27) homologous to human fortilin, therefore the biological activities of the Fm-Fortilin (FL) and its fragments (F2, F12, and F23) were investigated for potential use against HEMA toxicity from filling cement to pulp cell. The rFm-Fortilin FL, F2, 12, and F23 were expressed and assayed for proliferation activity. The rFm-Fortilin... More

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